Chapter 15
Mutation, DNA Repair, and Cancer
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Parts
- 1How mutations change a polypeptide5 min
- 2Where a mutation strikes4 min
- 3What causes mutations5 min
- 4Repairing damaged DNA4 min
- 5How cancer develops3 min
- 6Oncogenes4 min
- 7Tumor-suppressor genes4 min
- 8Silenced suppressors and the many steps to cancer4 min
Key terms
- gene mutation
- point mutation
- base substitution
- silent mutation
- missense mutation
- nonsense mutation
- frameshift mutation
- germ line
- germ-line mutation
- somatic mutation
- mosaic
- spontaneous mutation
- induced mutation
- mutagen
- deamination
- base analogue
- alkylation
- ionizing radiation
- thymine dimer
- direct repair
- nucleotide excision repair
- mismatch repair
- xeroderma pigmentosum
- carcinogen
- benign tumor
- malignant tumor
- oncogene
- proto-oncogene
- tumor-suppressor gene
- gene amplification
- chromosomal translocation
- retroviral insertion
- checkpoint protein
- p53
- Rb protein
- E2F
- epigenetic change